Plasma ALKAL2 levels are associated with coronary atherosclerosis in patients with type 2 diabetes mellitus
Authors' conclusion
Elevated plasma ALKAL2 levels are an independent risk factor for T2DM CAD and are associated with the severity of CAD.
Study context
- Population
- Patients with T2D undergoing coronary angiography, Ruijin Hospital, January 2019 to December 2020age- and sex-matched
- Participants
- 275 vs 275
- Comparison
- T2D patients with coronary artery disease (CAD) vs without CAD
- CADn = 275
- No CADn = 275reference
- Outcome
- Plasma ALKAL2 levels
Methodological detailsage- and sex-matched, single-centre, consecutive enrolment
- Age- and sex-matched
- Single-centre
- Consecutive enrolment
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Correlation of ALKAL2 with CAD severity
- Spearman rho
- 0.53, p < 0.001
Association of plasma ALKAL2 with CAD (multivariate logistic regression, adjusted for LDL-C, hsCRP and other traditional risk factors)
- OR
- 2.24 (95% CI 1.79-2.85); p < 0.001
Original publication
Plasma ALKAL2 levels are associated with coronary atherosclerosis in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. Published 8 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →