Assessment of left atrioventricular coupling and left atrial function impairment in diabetes with and without hypertension using cardiac magnetic resonance (CMR) feature tracking
Authors' conclusion
In DM patients, LV GLS showed a significant association with LA phasic strain. Hypertension was found to exacerbate the decline in LA booster strain and increase LACI in DM patients, indicating potential atrioventricular coupling index alterations.
Study context
- Population
- Patients with clinically diagnosed diabetes mellitus (DM) who underwent CMR at one hospital, December 2015 to June 2022
- Participants
- 176 patients
- Exposure
- DM with hypertension vs DM without hypertension
- DM + HPn = 103
- DM-HPn = 73reference
- Outcome
- LACI and LA function (reservoir, conduit and booster-pump strain and LA ejection fraction (LAEF))
Methodological detailsconsecutive recruitment, CMR feature tracking, single hospital
- Consecutive recruitment
- CMR feature tracking
- Single hospital
Main finding
As reported in the abstract
LA function and LACI, adjusted for age, sex, BSA and current smoking
- DM + HP vs DM-HP: P = 0.013
- DM + HP vs DM-HP: P = 0.017
- DM + HP vs DM-HP: P = 0.807
- DM + HP vs DM-HP: P = 0.006
- DM + HP vs DM-HP: P = 0.037
- DM + HP vs DM-HP: P = 0.019
- DM + HP vs DM-HP: P = 0.049
- Adjusted for age, sex, body surface area (BSA) and current smoking
Observational data: associations, not effects.
Further findings
Multivariate associations of LV GLS with left atrial (LA) strain and left atrioventricular coupling index (LACI) in DM
- LV GLS and εs, β
- −1.286, p < 0.001
- LV GLS and εe, β
- −0.919, p < 0.001
- LV GLS and εa, β
- −0.324, p = 0.036
- LV GLS and LACI, β (not significant)
- −0.003, p = 0.075
Hypertension as independent contributor in DM
- Decreased εa, β
- −2.508, p = 0.027
- Increased LACI, β
- 0.05, p = 0.011
Original publication
Assessment of left atrioventricular coupling and left atrial function impairment in diabetes with and without hypertension using CMR feature tracking. Cardiovasc Diabetol. Published 30 October 2023. doi:10.
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