Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort
Main finding · T2D risk, total artificial sweetenersResult — go to the resultHazard ratio 1.69 95% CI 1.45–1.97Authors' conclusion
Potential for reverse causality cannot be eliminated; however, many sensitivity analyses were computed to limit this and other potential biases. These findings of positive associations between artificial sweetener intakes and increased T2D risk strengthen the evidence that these additives may not be safe sugar alternatives. This study provides important insights in the context of on-going reevaluation of artificial sweeteners by health authorities worldwide.
Study context
- Population
- Adults in the web-based NutriNet-Santé study (France, 2009–2022); mean age 42.5 ± 14.6 years, 79.2% women972 incident T2D
- Participants
- 105,588 adults
- Exposure
- Higher consumers of artificial sweeteners vs nonconsumers
- Outcome
- Incident T2D
- Follow-up
- Median 9.1 years
Methodological detailsweb-based, Cox proportional hazard models adjusted for potential confounders, including weight variation during follow-up
- Web-based
- Cox proportional hazard models adjusted for potential confounders, including weight variation during follow-up
Main finding
T2D risk, total artificial sweeteners
Hazard ratio
1.69
95% CI 1.45–1.97
P < 0.001 for trend
Higher consumersvs Nonconsumers
HR 1.69 (95% CI 1.45–1.97); P for trend < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value | |
|---|---|---|---|
| T2D risk, aspartame | 1.63 (95% CI 1.38–1.93) | P for trend < 0.001 | |
| T2D risk, acesulfame-K | 1.70 (CI 1.42–2.04) | P for trend < 0.001 | |
| T2D risk, sucralose | 1.34 (CI 1.07–1.69) | P for trend = 0.013 | |
| 0.512Hazard ratio (log scale) |
Original publication
Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort. Diabetes Care. Published 25 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →