Associations between metabolic score for visceral fat and the risk of cardiovascular disease and all-cause mortality among populations with different glucose tolerance statuses

Zhu, Y; Zou, H; Guo, Y; Luo, P; Meng, X; Li, D; Xiang, Y; Mao, B; Pan, L; Kan, R; He, Y; Li, W; Liu, Z; Yang, Y; Xie, J; Zhang, B; Zhou, X; Hu, S; Yu, X

doi:10.1016/j.diabres.2023.110842

Type 2 & other diabetes

Associations between metabolic score for visceral fat and the risk of cardiovascular disease and all-cause mortality among populations with different glucose tolerance statuses

Diabetes Res Clin PractPublished 24 Jul 2023Cohort study

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Authors' conclusion

The METS-VF was associated with an increased risk of CVD events and all-cause mortality and could be used as a predictive index of the risk of CVD events and all-cause mortality among populations with different glucose tolerance statuses.

Study context

Population: Participants aged ≥40 years with different glucose tolerance statuses (normal glucose tolerance, prediabetes, diabetes)
Participants: 6,827 participants

Exposure: Metabolic score for visceral fat (METS-VF) quartile 4 vs quartile 1
Outcome: CVD events and all-cause mortality
Follow-up: 5.00 years

Main finding

As reported in the abstract

CVD events, by glucose tolerance status · 5.00 years

Quartile 4 vs Quartile 1Adjusted hazard ratio (95% CI)

Normal glucose tolerance

5.75(2.67–12.42)

Prediabetes

2.80(1.76–4.48)

Diabetes

3.31(1.28–8.54)

Cardiovascular disease (CVD) events: 338

Observational data: associations, not effects.

Further findings

Outcome	← Lower risk with quartile 4 ←→ Higher risk with quartile 4 →	aHR (95% CI)
All-cause mortality, by glucose tolerance status · 5.00 yearsQuartile 4vs Quartile 1Normal glucose tolerance	0.10.31310	2.80 (1.43–5.49)
All-cause mortality, by glucose tolerance status · 5.00 yearsQuartile 4vs Quartile 1Prediabetes	0.10.31310	4.15 (2.45–7.01)
All-cause mortality, by glucose tolerance status · 5.00 yearsQuartile 4vs Quartile 1Diabetes	0.10.31310	4.03 (1.72–9.42)
	0.10.31310Adjusted hazard ratio (log scale)

All-cause mortality, by glucose tolerance status — All-cause deaths: 307

Dose-response and prediction

Restricted cubic spline suggested a dose-response association of METS-VF with CVD events and all-cause mortality
AUC for CVD events and all-cause mortality higher for METS-VF than for other obesity and IR indexes in all glucose tolerance statuses

Original publication

Associations between metabolic score for visceral fat and the risk of cardiovascular disease and all-cause mortality among populations with different glucose tolerance statuses. Diabetes Res Clin Pract. Published 24 July 2023. doi:10.1016/j.diabres.2023.110842

Read the original article ↗

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