Handgrip strength cut-off points for identifying French adults at risk of type 2 diabetes
Authors' conclusion
Relative, but not absolute, handgrip strength is independently associated with T2D incidence and shows modest discriminative ability. Given its simplicity and cost-effectiveness, grip strength may be a useful screening tool in clinical and public health settings.
Study context
- Population
- French adults in the NutriNet-Santé cohort5,096 men
- Participants
- 18,519 adults
- Exposure
- Absolute vs relative handgrip strength (HGS) for T2D risk
- Outcome
- Incident T2D; HGS cut-off points detecting T2D risk
- Follow-up
- 9.8 years
Main finding
As reported in the abstract
Incident T2D by HGS
- Incident T2D cases validated
- 329
- Higher relative HGS associated with lower risk; HR for HGS relative to body weight
- 1.30 (1.07-1.58) (95% CI)
- AUC, relative HGS
- 0.623-0.675
- AUC, absolute HGS
- ≤ 0.44
- Optimal cut-offs, dominant hand
- 0.446 kg/kg and 1.086 kg/kg/m²
- Optimal cut-offs, non-dominant hand
- 0.397 kg/kg and 1.033 kg/kg/m²
- Low relative HGS and increased T2D risk, HRs
- 1.42-1.68
Observational data: associations, not effects.
Original publication
Handgrip strength cut-off points for identifying French adults at risk of type 2 diabetes. Diabetes Metab. Published 9 November 2025. doi:10.
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