Apparent Saturation of Branched-Chain Amino Acid Catabolism After High Dietary Milk Protein Intake in Healthy Adults
Authors' conclusion
BCAA catabolism is markedly influenced by protein content of the test meal. We present novel evidence for the apparent saturation of the BCAA degradation pathway in the acute postprandial phase up to 5 hours after consumption.
Study context
- Population
- Healthy adults (TOMI Add-On Study); 9 blood samples over 5 hourscrossover
- Participants
- 27 adults
- Comparison
- Higher-protein vs lower-protein young child formula as test meal
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
Postprandial plasma BCAA, BCKA and acylcarnitines · 5 postprandial hours
- Mean concentrations of branched-chain amino acids (BCAA), BCKA and acylcarnitines significantly higher after HP than LP, except the BCKA α-ketoisovalerate (KIVA)
- KIVA showed higher postprandial concentrations after LP
- With increasing mean BCAA, corresponding BCKA, acylcarnitines and urea increased until a breakpoint, after which degradation products decreased (all metabolites except valine, KIVA and Carn C4:0-iso)
Original publication
Apparent Saturation of Branched-Chain Amino Acid Catabolism After High Dietary Milk Protein Intake in Healthy Adults. J Clin Endocrinol Metab. Published 20 September 2024. doi:10.
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