Pituitary Apoplexy: Comorbidities, Management, and Outcomes—A Spanish Observational Multicenter Study
An erratum to this article was published (J Clin Endocrinol Metab, 17 Jun 2025 ↗)
Authors' conclusion
There is a high burden of cardiovascular risk factors among patients with PA, suggesting that metabolic factors may play a potential role in the development of PA. This underscores the need for comprehensive management of these conditions in addition to treating the apoplexy itself in this population. Surgical management has a relevant place in PA approach mainly in patients with higher PAS. However, it leads a permanent vasopressin deficit more frequently than a conservative approach.
Study context
- Population
- Patients with acute pituitary apoplexy in Spain; median age 59.3 years, 66.8% men; nonfunctioning adenomas 77.9%
- Participants
- 301 patients
- Exposure
- Surgical vs conservative management of pituitary apoplexy (PA)
- Surgeryn = 209
- Conservativen = 92reference
- Outcome
- Cardiovascular risk factor prevalence, PA patients vs Spanish age-adjusted population
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
- Diabetes: 20.3% vs 13.9% (PA vs Spanish population), P < .01
- Hypertension: 48.8% vs 33.4% (PA vs Spanish population), P < .01
- Dyslipidemia: 44.2% vs 23.3% (PA vs Spanish population), P < .01
- Age-adjusted population prevalence
Observational data: associations, not effects.
Further findings
Tumour size
P < 0.01
Chiasmal compression
P < 0.01
Chiasmal compression
- Surgical patients had higher pituitary apoplexy score (PAS) values
Anterior pituitary hormonal deficits at follow-up
- No statistically significant differences between treatments
Safety
Permanent vasopressin deficiency · follow-up
P < 0.01
Original publication
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