Greater Urinary Calcium Excretion Is Associated With Diminished Bone Accrual in Youth With Type 1 Diabetes
Authors' conclusion
Urinary calcium excretion was negatively associated with bone accrual in this cohort of youth with T1D. Mechanistic studies are needed to determine if interventions to reduce urinary calcium excretion could increase bone accrual and reduce skeletal fragility in people with T1D.
Study context
- Population
- Youth with T1D aged 6 to 20 yearstwo cohorts
- Participants
- 50 vs 99
- Exposure
- Bone accrual vs Urinary calcium excretion
- Bone accrualn = 50
- Urinary calcium excretionn = 99
- Outcome
- Whole body less head BMC (WBLH BMC) velocity Z-score and fractional excretion of calcium (FeCa)
- Follow-up
- 12 months
Methodological detailslongitudinal bone accrual cohort, cross-sectional urinary calcium excretion cohort
- Longitudinal bone accrual cohort
- Cross-sectional urinary calcium excretion cohort
Main finding
As reported in the abstract
FeCa vs WBLH BMC velocity Z-score (bone accrual cohort)
Fractional excretion of calcium (FeCa) negatively associated with WBLH BMC velocity Z-score, ρ
−0.47
P = .001
WBLH BMC velocity Z-score vs healthy reference dataset (lower)
−0.3 ± 1.0
P = .03
Observational data: associations, not effects.
Further findings
Determinants of FeCa in multivariable regression (urinary calcium excretion cohort)
- Intact PTH, β
- −0.4, P = .01
- Beta c-telopeptide, β
- 0.35, P = .007
- HbA1c, β
- 0.08, P = .03
- Urine fractional glucose excretion, β
- 0.07, P = .03
- Models included known determinants of urinary calcium excretion; either HbA1c or urine fractional glucose excretion
Original publication
Greater Urinary Calcium Excretion Is Associated With Diminished Bone Accrual in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. Published 20 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →