Analysis of FNAC indication in thyroid nodules assessed as low risk according to various TIRADSs
Authors' conclusion
How to save on UN-FNACs in low-risk TNs is challenging. Although ACR-TIRADS can be effective in reducing the total number of biopsies, the rate of UN-FNAC remains significant. Alternative strategies should be developed.
Study context
- Population
- Patients undergoing thyroid surgery (January 2019–August 2024) with preoperative thyroid US; thyroid nodules assessed as TIRADS 3 (low risk)
- Participants
- 284 thyroid nodules
- Exposure
- ACR-TIRADS vs EU-TIRADS vs K-TIRADS in TIRADS 3 thyroid nodules
- Outcome
- Rate of unnecessary biopsy (UN-FNAC), with histology as reference standard
Methodological detailsconsecutive series of surgical patients, histology as reference standard
- Consecutive series of surgical patients
- Histology as reference standard
Main finding
As reported in the abstract
Overall rate of UN-FNAC
Observational data: associations, not effects.
Further findings
Risk of malignancy · higher than expected
Thyroid nodules with indication for biopsy — K-TIRADS vs ACR-TIRADS · significantly higher with K-TIRADS
P = 0.003
Cancers with indication for biopsy
Original publication
Analysis of FNAC indication in thyroid nodules assessed as low risk according to various TIRADSs. Eur Thyroid J. Published 3 July 2025. doi:10.
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