An Increase in Plasma Sodium Levels Is Associated With an Increase in Osteoblast Function in Chronic Syndrome of Inappropriate Antidiuresis (SIAD)
Authors' conclusion
An increase in plasma sodium levels in outpatients with chronic hyponatremia due to SIAD, even when mild, was associated with an increase in bone formation index (P1NP/CTX) triggered by an increase in P1NP, a surrogate marker of osteoblast function.
Study context
- Population
- Outpatients with chronic SIAD; 6 women, median age 73 yearscrossover
- Participants
- 11 outpatients
- Comparison
- Change in plasma sodium vs change in bone turnover markers
- Primary endpoint
- Relationship between change in bone formation index (BFI, P1NP/CTX) and change in plasma sodium
Methodological detailspredefined secondary analysis, double-blind, crossover, placebo-controlled, December 2017 to August 2021
- Predefined secondary analysis
- Double-blind
- Crossover
- Placebo-controlled
- December 2017 to August 2021
Primary result
As reported in the abstract
Association of sodium change with bone markers
Correlation of sodium change with bone formation index (BFI) change: ρ (P < .001)
.55
Correlation of sodium change with P1NP change: ρ (P = .004)
.45
Increase in BFI per 1 mmol/l sodium increase
5.21
95% CI 1.41–9.00P = .013
Increase in P1NP per 1 mmol/l sodium increase, µg/l
1.48
95% CI .26–2.62P = .03
Original publication
An Increase in Plasma Sodium Levels Is Associated With an Increase in Osteoblast Function in Chronic SIAD. J Clin Endocrinol Metab. Published 25 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →