Altered gray matter structural covariance networks in young adults with obesity
Authors' conclusion
Young adults with obesity exhibited abnormal nodal network measures in widespread brain regions involved in default mode network, central executive network and salience network. These findings indicate the adverse effects of obesity on young adults might be associated with the altered triple network.
Study context
- Population
- Young adults from the Human Connectome Project Release S1200 dataset; MRI with clinical and neuropsychological assessments
- Participants
- 243 vs 243
- Exposure
- Young adults with obesity vs matched lean individuals
- Obesityn = 243
- Leann = 243reference
- Outcome
- Gray matter structural covariance networks (SCNs) based on cortical thickness and cortical surface area (global and nodal network measures)
Methodological detailsmatched case-control
- Matched case-control
Main finding
As reported in the abstract
- Lower cortical surface area of left entorhinal cortex with obesity
- Higher cortical thickness of left rostral anterior cingulate cortex and right superior parietal lobule with obesity
- Lower cortical thickness of left temporal pole with obesity
- No significant group differences in global network measures
- Altered nodal network measures with obesity in left posterior cingulate cortex, bilateral superior frontal gyrus, left entorhinal cortex and right insula
- Nonparametric permutation tests
Observational data: associations, not effects.
Original publication
Altered gray matter structural covariance networks in young adults with obesity. Int J Obes (Lond). Published 18 December 2024. doi:10.
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