Adult-based Genetic Risk Scores for Insulin Resistance Associate With Cardiometabolic Traits in Children and Adolescents
Authors' conclusion
Adult-derived GRSs for IR are significantly associated with cardiometabolic traits in children and adolescents. If validated in independent study samples, our findings suggest the contribution of adult-based GRSs in assessing IR-related cardiometabolic risk in youth.
Study context
- Population
- Children and adolescents with and without obesity
- Participants
- 1,680 vs 1,804
- Comparison
- Adult-derived insulin resistance (IR) genetic risk scores and cardiometabolic traits
- Obesityn = 1,680
- Without obesityn = 1,804
- Outcome
- Associations of adult-derived GRSs for IR with cardiometabolic traits
Methodological detailsweighted genetic risk scores, additive genetic model, linear and logistic regression, 3 genetic risk scores (GRSs) built from previous GWAS: fasting (IR-GRS27), OGTT (IR-GRS8), IR-related phenotypes (IR-GRS51)
- Weighted genetic risk scores
- Additive genetic model
- Linear and logistic regression
- 3 GRSs built from previous GWAS: fasting (IR-GRS27), OGTT (IR-GRS8), IR-related phenotypes (IR-GRS51)
Performance
As reported in the abstract
Associations of IR-GRSs with cardiometabolic traits
- IR-GRS27 associated with higher fasting insulin, C-peptide, triglycerides (TG), gamma-glutamyl transferase, ALT and HOMA-IR
- IR-GRS27 associated with higher prevalence of IR and ALT
- IR-GRS51 associated with higher TG and lower HDL-C
- IR-GRS8 associated with lower total cholesterol, LDL-C and increased ALT
- IR-GRS27 and IR-GRS8 associated with higher prevalence of IR and steatotic liver disease, respectively
Original publication
Adult-based Genetic Risk Scores for Insulin Resistance Associate With Cardiometabolic Traits in Children and Adolescents. J Clin Endocrinol Metab. Published 18 December 2024. doi:10.
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