Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease – a cross-sectional study
Authors' conclusion
We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.
Study context
- Population
- Patients with autoimmune Addison's disease (AAD) and matched controls
- Participants
- 43 vs 43
- Exposure
- Patients with AAD vs matched controls
- AADn = 43
- Controlsn = 43reference
- Outcome
- Serum levels of 177 cardiovascular and inflammatory biomarkers
Methodological detailsmatched controls
- Matched controls
Main finding
As reported in the abstract
Biomarkers significantly differing between AAD and controls; all but 1 (ST1A1) higher in AAD
19
Biomarkers significantly higher in female patients vs controls (IL6, MCP1, GAL9, SPON2, DR4, RAGE, TNFRSF9, PGF)
8
Biomarkers differing between male patients and controls
0
Observational data: associations, not effects.
Further findings
RAGE correlation with frequency of adrenal crises
- R
- 0.415, P = .006
- Not significant after correction for multiple testing
RAGE correlation with AddiQoL-30 scores
- R
- −0.347, P = .028
- Not significant after correction for multiple testing
Change in PDL2 and leptin 60 min after 250 µg tetracosactide (ACTH) in AAD without residual adrenocortical function (RAF)
- PDL2
- −0.15 NPX, P = .0001
- Leptin
- −0.25 NPX, P = .0003
Original publication
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