All-Cause Mortality Differentials by Diabetes Status and Serum Neurofilament Light-Chain Levels in US General Adults
Main finding · All-cause mortality incidence rate (per 1000 person-years)Result — go to the resultHazard ratio 7.06 95% CI 3.52∼14.16Authors' conclusion
In general US adults with DM, elevated sNFLs were associated with higher all-cause mortality specifically, supporting an important role of sNFLs in predicting health outcome in individuals with DM.
Study context
- Population
- US adults aged 20 to 75 years with sNFL measurements, NHANES 2013–201485 died
- Participants
- 2,071 adults
- Exposure
- Joint categories of DM status and sNFL
- Outcome
- All-cause mortality
- Follow-up
- Median 6.1 years
Main finding
As reported in the abstract
All-cause mortality incidence rate (per 1000 person-years)
Hazard ratio
7.06
95% CI 3.52∼14.16
By group
LgNfl >1.48 + DMvs No DM, LgNfl ≤1.48
HR 7.06 (95% CI 3.52∼14.16)
Observational data: associations, not effects.
Original publication
All-Cause Mortality Differentials by Diabetes Status and Serum Neurofilament Light-Chain Levels in US General Adults. J Clin Endocrinol Metab. Published 27 February 2024. doi:10.
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