Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels
Authors' conclusion
In conclusion, magnesium supplementation modulates the function of CD4+ and CD8+ T-cells in people with type 2 diabetes and low serum magnesium levels.
Study context
- Population
- Adults with insulin-treated T2D and low magnesium levels (0.73 ± 0.05 mmol/L); 7 males, mean ± SD age 67 ± 7 years, BMI 31 ± 5 kg/m², HbA1c 7.5 ± 0.9%crossover
- Participants
- 12 adults
- Comparison
- Magnesium supplementation vs placebo
Methodological detailsdouble-blind, placebo-controlled, 2-period, crossover, multidimensional immunophenotyping
- Double-blind
- Placebo-controlled
- 2-period
- Crossover
- Multidimensional immunophenotyping
Primary result
As reported in the abstract
Immunophenotype: T-cell function after ex vivo stimulation
- Interferon-γ production from PMA/ionomycin stimulated CD8+ T-cells and T-helper 1 cells lower after magnesium vs placebo
- IL4/IL5/IL13 production from T-helper 2 cells lower after magnesium vs placebo
- No effect on immune cell numbers, ex vivo monocyte function and circulating inflammatory proteins
- Tendency for lower high sensitivity C-reactive protein after magnesium vs placebo
Further findings
Serum magnesium and urinary magnesium excretion
- Significantly increased with magnesium vs placebo
Original publication
Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels. J Clin Endocrinol Metab. Published 27 February 2024. doi:10.
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