Aldosterone is Associated With New-onset Cerebrovascular Events in Patients With Hypertension and White Matter Lesions: A Cohort Study
Authors' conclusion
Our study identified a linear association between PAC and the risk of new-onset cerebrovascular events in patients with hypertension and WMLs.
Study context
- Population
- Hospitalized patients with hypertension and white matter lesions; mean age 60.9 ± 10.2 years, 53.4% male
- Participants
- 1,041 patients
- Exposure
- Higher vs lower baseline plasma aldosterone concentration
- Outcome
- New-onset cerebrovascular events including intracerebral hemorrhage and stroke
- Follow-up
- Median 42 months (IQR 25-67)
Main finding
As reported in the abstract
New-onset cerebrovascular events · median follow-up 42 months
Hazard ratio (95% CI)P value
Per 1 ng/dL PAC increasemultivariate-adjusted
1.03(1.01–1.06)
P < 0.01Per 5 ng/dL PAC increasemultivariate-adjusted
1.17(1.06–1.31)
P < 0.01Per 10 ng/dL PAC increasemultivariate-adjusted
1.41(1.14–1.75)
P < 0.01Q4vs Q1
2.12(1.18–3.79)
P < 0.05- Patients with new-onset cerebrovascular events
- 92
Observational data: associations, not effects.
Original publication
Aldosterone is Associated With New-onset Cerebrovascular Events in Patients With Hypertension and White Matter Lesions: A Cohort Study. Endocr Pract. Published 9 May 2024. doi:10.
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