Alcohol Intake, Drinking Pattern, and Risk of Type 2 Diabetes in Three Prospective Cohorts of U.S. Women and Men
Authors' conclusion
Light to moderate alcohol consumption, especially regular light drinking, was associated with a lower risk of T2D in both men and women.
Study context
- Population
- US women and men in the Nurses' Health Study, Nurses' Health Study II and Health Professionals Follow-up Study; former regular drinkers excluded from baseline nondrinkers20,551 T2D cases
- Participants
- 200,969 women
- Exposure
- Alcohol intake and drinking frequency vs nondrinkers or lower intake/frequency
- Outcome
- Incident T2D
- Follow-up
- Over 3 decades
Methodological detailsthree cohorts (Nurses' Health Study (NHS), NHSII, HPFS), Cox models
- Three cohorts (NHS, NHSII, HPFS)
- Cox models
Main finding
As reported in the abstract
T2D risk by drinking frequency
5-6 days vs 1-2 days per weekHazard ratio (95% CI)
NHS
0.73(0.65–0.83)
NHSII
0.73(0.62–0.86)
HPFS
0.76(0.67–0.86)
Observational data: associations, not effects.
Further findings
Joint modelling of frequency and amount
- Lower T2D risk among drinkers primarily driven by drinking frequency
- Inverse association began at 1-2 days/week in women and 3-4 days/week in men; strongest for ≥5 days/week, regardless of <10 g or ≥30 g per drinking day
Sensitivity analyses
- Association robust to extended latency periods and alternative modelling of exposure
Original publication
Alcohol Intake, Drinking Pattern, and Risk of Type 2 Diabetes in Three Prospective Cohorts of U.S. Women and Men. Diabetes Care. Published 18 February 2025. doi:10.
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