Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study
Main finding · Total MVD composite score (SD)Result — go to the resultbeta −0.10 SD 95% CI −0.19 to −0.01Authors' conclusion
The present cross-sectional, population-based study found evidence that alcohol consumption may have an effect on MVD. Hence, although increasing alcohol consumption cannot be recommended as a policy, this study suggests that prevention of MVD may be possible through dietary interventions.
Study context
- Population
- The Maastricht Study participants; 50.9% men, mean age 60 years, 27.5% with T2D
- Participants
- 3,120 participants
- Exposure
- Alcohol consumption categories and per unit
- Outcome
- Total MVD composite score (brain, retina, skin, kidney, blood measures; expressed in SD)
Methodological detailspopulation-based, T2D oversampled by design
- Population-based
- T2D oversampled by design
Main finding
Total MVD composite score (SD)
beta
−0.10 SD
95% CI −0.19 to −0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
Interaction: shape of curve by subgroup
- Shape of the curve differed with sex
- P for interaction = 0.03
- Shape of the curve differed with history of CVD
- P for interaction < 0.001
- Shape of the curve differed with glucose metabolism status
- P for interaction = 0.02
Original publication
Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study. Cardiovasc Diabetol. Published 24 March 2023. doi:10.
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