The role of irisin and asprosin level in the pathophysiology of prediabetes
Authors' conclusion
Both irisin and asprosin have been found to be related to the prediabetes pathway and it has been shown that these molecules may be useful in daily clinical practice with diagnostic performances similar to those of the HOMA index and insulin.
Study context
- Population
- People aged 18–65 years with prediabetes or healthy
- Participants
- 100 people
- Exposure
- Prediabetes vs healthy
- Prediabetesn = 60
- Healthyn = 40reference
- Outcome
- Role of irisin and asprosin in the physiopathology of prediabetes
Methodological detailssingle-center, 3-month lifestyle-change follow-up
- Single-center
- 3-month lifestyle-change follow-up
Main finding
As reported in the abstract
Irisin and asprosin levels, prediabetes vs healthy
- Irisin levels lower and asprosin levels higher in patients with prediabetes
- Prediabetes vs Healthy: P < 0.001
Observational data: associations, not effects.
Further findings
Diagnostic performance for prediabetes
Sensitivity
Specificity
Change after 3-month lifestyle-change program (prediabetes)
- Insulin, HOMA index and asprosin decreased; irisin elevated
- P < 0.001
Diagnostic performance for prediabetes
- Irisin diagnostic performance similar to insulin and HOMA index; asprosin similar to glucose, insulin and HOMA index
Original publication
The role of irisin and asprosin level in the pathophysiology of prediabetes. Diabetes Res Clin Pract. Published 24 March 2023. doi:10.
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