Lipids & metabolic liver disease
Alcohol and steatotic liver disease exhibit divergent associations with high plasma small dense low-density lipoprotein cholesterol (LDL-C) concentration
Authors' conclusion
Alcohol exposure contributes to an atherogenic sdLDL-C phenotype beyond conventional fasting lipids within contemporary SLD categories, indicating potential relevance for risk profiling in MetALD/ALD.
Study context
- Population
- Adults undergoing health screenings in Niigata, Japan, April 2024–March 2025
- Participants
- 55,745 adults
- Exposure
- Steatotic liver disease (SLD) status and alcohol consumption categories
- Outcome
- High sdLDL-C (≥35 mg/dL, directly measured)
Main finding
As reported in the abstract
Crude prevalence of high sdLDL-C
SLD(+)/excessive alcohol consumption
76.4%
- Crude prevalence of high small dense low-density lipoprotein cholesterol (sdLDL-C) influenced by SLD and alcohol consumption; highest in SLD(+)/excessive alcohol consumption
- 76.4%
Observational data: associations, not effects.
Original publication
Alcohol and steatotic liver disease exhibit divergent associations with high plasma small dense LDL-C concentration. J Clin Endocrinol Metab. Published 19 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →