Lipids & metabolic liver disease
Discordant high remnant cholesterol with low-density lipoprotein cholesterol (LDL-C) increases the metabolic dysfunction-associated steatotic liver disease risk in patients with type 2 diabetes mellitus
Authors' conclusion
Discordantly high RC was associated with higher MASLD risk than discordantly high LDL-C. Our findings suggest that RC may serve as a potential target for prevention and intervention for MASLD.
Study context
- Population
- Hospitalized patients with T2D; median age 62.0 years
- Participants
- 26,302 patients
- Exposure
- Discordantly high remnant cholesterol (RC) vs discordantly high LDL-C
- Outcome
- MASLD
Methodological detailshospitalized patients, logistic regression, three discordance approaches: clinical cut-off points, differences of >10 percentile points and residuals
- Hospitalized patients
- Logistic regression
- Three discordance approaches: clinical cut-off points, differences of >10 percentile points and residuals
Main finding
As reported in the abstract
MASLD risk
- Prevalence of MASLD
- 48.3%
- Residual approach, model with LDL-C and RC residual: OR for RC residual
- 1.26 (95% CI 1.22 to 1.30)
- Residual approach, model with LDL-C and RC residual: OR for LDL-C
- 1.04 (95% CI 1.01 to 1.07)
- Residual approach, model with RC and LDL-C residual: OR for RC
- 1.24 (95% CI 1.20 to 1.29)
- Residual approach, model with RC and LDL-C residual: OR for LDL-C residual
- 1.09 (95% CI 1.06 to 1.12)
Observational data: associations, not effects.
Original publication
Discordant high remnant cholesterol with LDL-C increases the metabolic dysfunction-associated steatotic liver disease risk in patients with type 2 diabetes mellitus. BMJ Open Diabetes Res Care. Published 16 June 2026. doi:10.
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