Alanine to glycine ratio is a novel predictive biomarker for type 2 diabetes mellitus
Authors' conclusion
The combination of obesity and the alanine/glycine ratio can be used to evaluate the diabetes risk.
Study context
- Population
- 1813 individuals without T2D (incidence) and 451 with newly diagnosed T2D (remission)
- Outcome
- T2D incidence and T2D remission predicted by metabolite ratios
Methodological detailsCox proportional hazards regression, ROC analysis, external validation
- Cox proportional hazards regression
- ROC analysis
- External validation
Main finding
As reported in the abstract
Alanine/glycine and T2D incidence, HR per SD (p < .001)
1.24
Hydroxy sphingomyelin C22:2 and T2D remission, HR per SD (p = .029)
1.32
Observational data: associations, not effects.
Further findings
T2D incidence by alanine/glycine and obesity subgroups
- High alanine/glycine plus obesity had the highest risk of T2D incidence (p < .001)
External validation
- Alanine/glycine as T2D risk marker validated in independent external data
Original publication
Alanine to glycine ratio is a novel predictive biomarker for type 2 diabetes mellitus. Diabetes Obes Metab. Published 11 December 2023. doi:10.
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