Age and Red Blood Cell Parameters Mainly Explain the Differences Between HbA1c and Glycemic Management Indicator Among Patients With Type 1 Diabetes Using Intermittent Continuous Glucose Monitoring
Authors' conclusion
The difference between HbA1c and GMI is clinically relevant in a high percentage of cases. Age and easily accessible hematological parameters (MCV and RDW) can help to interpret these differences.
Study context
- Population
- Patients with T1D using Freestyle Libre 2 isCGM with ≥1 HbA1c measurement after starting continuous glucose monitoring (CGM), sharing data via Libreview; 14-day reports ending on HbA1c date with sensor use ≥70%646 HbA1c values
- Participants
- 339 patients
- Outcome
- Factors explaining the discrepancy between HbA1c and GMI
Methodological detailsmultilevel model
- Multilevel model
Main finding
As reported in the abstract
HbA1c–GMI discrepancy
Absolute difference between HbA1c and glucose management indicator (GMI) <0.3%
38.7% of cases
Observational data: associations, not effects.
Original publication
Age and Red Blood Cell Parameters Mainly Explain the Differences Between HbA1c and Glycemic Management Indicator Among Patients With Type 1 Diabetes Using Intermittent Continuous Glucose Monitoring. J Diabetes Sci Technol. Published 11 August 2023. doi:10.
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