Age Difference in the Connection Between Systemic Inflammatory Response and Metabolic Syndrome
An erratum to this article was published (J Clin Endocrinol Metab, 18 Feb 2025 ↗)
Authors' conclusion
Our research highlights the predictive significance of SII in forecasting the incidence of MetS in young and middle-aged populations. The differences in inflammatory mechanisms across various age groups necessitate further research for exploration.
Study context
- Population
- Adults from the 2001–2018 National Health and Nutrition Examination Survey6,739 with metabolic syndrome (MetS)
- Participants
- 15,959 adults
- Exposure
- SII quartiles
- Outcome
- MetS
Methodological detailsNHANES 2001-2018, weighted multivariable logistic regression, restricted cubic spline, Multiple imputation confirmed the robustness of results
- NHANES 2001-2018
- Weighted multivariable logistic regression
- Restricted cubic spline
- Multiple imputation confirmed the robustness of results
Main finding
As reported in the abstract
Association of SII with MetS
- SII and MetS, OR
- 1.56 (95% CI 1.37-1.79; P < .001)
- Shape of association
- inverted U-shaped curve
Observational data: associations, not effects.
Further findings
SII and MetS, elderly subgroup
- OR in elderly (95% CI .95-1.23; P = .248), not significant
- 1.08
- Association significant in 18 to 65 age group
- Age and alcohol consumption modified the association
MetS components
- Elevated SII is an independent risk factor for the 5 components of MetS
Original publication
Age Difference in the Connection Between Systemic Inflammatory Response and Metabolic Syndrome. J Clin Endocrinol Metab. Published 25 September 2024. doi:10.
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