Deciphering the Presentation and Etiologies of Hypophysitis Highlights the Need for Repeated Systematical Investigation
Authors' conclusion
A systemic etiology of hypophysitis was found in almost half of the patients. Pituitary disorders preceded the systemic disease in a quarter of the cases. This emphasizes the importance of a systematic repeated workup looking for a secondary etiology of hypophysitis in these patients.
Study context
- Population
- Patients >15 years with hypophysitis diagnosed January 2014–October 2023, excluding ICI-related hypophysitis64% women
- Participants
- 61 patients
- Outcome
- Presentation and etiologies of hypophysitis
- Follow-up
- At diagnosis
Methodological detailssingle-centre, university referral hospital
- Single-centre
- University referral hospital
Main finding
As reported in the abstract
at diagnosis
- Polyuria-polydipsia
- 64%
- Headache
- 48%
- Asthenia
- 44%
- ≥1 anterior pituitary deficiency
- 91.5%
- Vasopressin deficiency
- 56%
- Abnormal MRI
- 97%
- Secondary hypophysitis
- 46% (n = 28)
- Sarcoidosis
- 28% (n = 17)
- L (Langerhans) group histiocytoses
- 13.1% (n = 8)
- Secondary hypophysitis: pituitary deficiency preceded systemic manifestations
- 23%
- Secondary hypophysitis: pituitary deficiency concomitant with systemic manifestations
- 23%
Observational data: associations, not effects.
Further findings
Treatment (glucocorticoids, surgery)
- Treated
- 36%
- Treatment without improvement of pituitary hormone deficits
Original publication
Deciphering the Presentation and Etiologies of Hypophysitis Highlights the Need for Repeated Systematical Investigation. J Clin Endocrinol Metab. Published 23 September 2024. doi:10.
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