Age-Dependent and Body Composition–Dependent Association of Child Gut Microbial Enterotype With Puberty Timing: A Chinese Cohort
Authors' conclusion
Our findings supported a role for gut microbial communities in pubertal development, in which younger children with higher body mass seems more sensitive.
Study context
- Population
- Children aged 6–8 years at entry, Chinese Adolescent Cohort Study, followed annually to age 15 years; fecal samples annually since 2019 (16S rRNA sequencing)
- Participants
- 1,826 children
- Exposure
- Bacteroides-rich vs Prevotella-rich gut microbial enterotype
- Bacteroides-richn = 1,234
- Prevotella-richn = 592reference
- Outcome
- Puberty timing (menarche/voice break)
Main finding
Menarche/voice break
Hazard ratio
0.53
95% CI 0.28–0.98
P = 0.02
Events by group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Interaction with age and body mass index (BMI) standard deviation score (SDS)
- Association more pronounced among younger children with higher BMI SDS
- P for interaction = 0.006
Original publication
Age-Dependent and Body Composition–Dependent Association of Child Gut Microbial Enterotype With Puberty Timing: A Chinese Cohort. J Clin Endocrinol Metab. Published 24 February 2023. doi:10.
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