Age at Menarche Mediating Visceral Adipose Tissue's Influence on Pre-eclampsia: A Mendelian Randomization Study
Main finding · PE risk (univariable MR)Result — go to the resultOdds ratio 1.65 95% CI 1.23–2.20Authors' conclusion
Our findings provided evidence of the causal relationship between VAT and PE and proved VAT could accelerate AAM and then contribute to the risk of incident PE.
Study context
- Population
- Pre-eclampsia (PE) summary data from FinnGen GWAS (3556 cases, 114,735 controls); 70 genetic variants associated with predicted visceral adipose tissue (VAT) in 161,149 European women from UK Biobank3,556 PE cases · 114,735 controls
- Comparison
- Genetically predicted higher VAT volume
- Outcome
- Causal effect of VAT on PE risk, and mediation by age at menarche (AAM)
Methodological detailsunivariable Mendelian randomization (MR), multivariable MR, two-step MR mediation analysis, inverse variance weighted
- Univariable MR
- Multivariable MR
- Two-step MR mediation analysis
- Inverse variance weighted
Main finding
PE risk (univariable MR)
Odds ratio
1.65
95% CI 1.23–2.20
Higher VAT volume
OR 1.65 (95% CI 1.23–2.20)
As reported in the abstract
Further findings
| Outcome | Beta (95% CI) |
|---|---|
| AAM (univariable MR)Higher VAT associated with advancement of AAM | −0.33 (−0.49 to −0.16) |
Proportion of VAT effect on PE mediated by age at menarche (AAM) (two-step MR)
- Proportion mediated by AAM
- 14.3%
Original publication
Age at Menarche Mediating Visceral Adipose Tissue's Influence on Pre-eclampsia: A Mendelian Randomization Study. J Clin Endocrinol Metab. Published 3 October 2022. doi:10.
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