Metabolic Dysregulation in Adult Survivors of Pediatric Hematopoietic Stem Cell Transplantation: The Role of Incretins
Authors' conclusion
This study demonstrates an altered production of incretin hormones in HSCT survivors previously treated with TBI, developing dyslipidemia and abdominal adiposity.
Study context
- Population
- Male adult survivors of pediatric hematopoietic stem cell transplantation (HSCT), Danish national referral center for HSCT
- Participants
- 42 vs 15
- Exposure
- Male HSCT survivors vs healthy controls
- HSCT survivorsn = 42
- Healthy controlsn = 15reference
- Outcome
- Glucose metabolism and incretin hormones (by OGTT) and MetS criteria
Methodological detailscohort, age- and sex-matched controls, single national referral center, hypothesis formulated before data collection
- Cohort
- Age- and sex-matched controls
- Single national referral center
- Hypothesis formulated before data collection
Main finding
As reported in the abstract
GLP-1, GIP and glucagon during OGTT
Survivors with metabolic syndrome (MetS)
24%
Observational data: associations, not effects.
Further findings
Fasting glucagon in patients with hypertriglyceridemia
- Fasting glucagon significantly higher with hypertriglyceridemia: MD 6.1 pmol/L; 95% CI 1.5-10.8; P = 0.01
Fasting glucagon correlations
- Correlation with HDL: MD 4.7 mmol/L; 95% CI −0.6 to 9.9; P = 0.08
- Android-gynoid ratio: r = 0.6, P = 0.0001
- WHR: r = 0.5, P = 0.002
GIP and triglyceride
- GIP correlating positively with triglyceride: MD 60%; 95% CI 44-82; P = 0.002
GIP levels in patients treated with TBI
- GIP significantly increased with TBI: MD 165%; 95% CI 118-230; P = 0.004
- TBI a significant risk factor for MetS
Original publication
Metabolic Dysregulation in Adult Survivors of Pediatric Hematopoietic Stem Cell Transplantation: The Role of Incretins. J Clin Endocrinol Metab. Published 1 October 2022. doi:10.
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