Age and sex differences of cardiovascular and mortality risks in Korean type 2 diabetes and prediabetes: An 8 million Korean nationwide population-based cohort study
Authors' conclusion
Prediabetes and T2DM are major CVD/mortality risk factors in Koreans, particularly in the young and with early-onset T2DM. These findings emphasize the need for targeted screening, proactive management, and glycemic control in vulnerable groups (young, women, elderly with T2DM) to mitigate adverse outcomes.
Study context
- Population
- Adults ≥30 years without prior cardiovascular disease (CVD), Korea
- Participants
- 8,060,298 adults
- Exposure
- Prediabetes and T2D vs normoglycaemia
- Outcome
- CVD and mortality outcomes
- Follow-up
- Median 9.3 years
Methodological detailsKorean National Health Insurance System database (2009-2019)
- Korean National Health Insurance System database (2009-2019)
Main finding
As reported in the abstract
CVD and mortality risks
- Both prediabetes and T2D significantly increased CVD and mortality risks
Observational data: associations, not effects.
Further findings
CVD/mortality risk by age
- Risk notably higher in adults under 40
- Significant T2D-related CVD/mortality risk persisted in those over 80
CVD/mortality risk by glycaemic control
- Controlled T2D showed more favourable risks than poor glycaemic control
CVD/mortality risk by sex
- Women with T2D initially showed higher risks than men, partly explained by comorbidities
Original publication
Age and sex differences of cardiovascular and mortality risks in Korean type 2 diabetes and prediabetes: An 8 million Korean nationwide population-based cohort study. Diabetes Res Clin Pract. Published 5 August 2025. doi:10.
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