Type 2 & other diabetes

DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial

Nat MedPublished Randomised crossover feeding trial

Authors' conclusion

These results suggest that the DASH4D diet is a promising nutritional approach to substantially improve glycemic control in adults with type 2 diabetes.

Study context

Population
Participants with T2D
Participants
89 participants
Comparison
DASH4D diet vs comparison diet, each with higher or lower sodium
Primary endpoint
Mean glucose; time in range (glucose 70–180 mg dl-1); CV, by 14 days of CGM during each feeding period
Follow-up
Each 5-week feeding period
Methodological detailsisocaloric diets
  • Isocaloric diets

Primary result

As reported in the abstract

Mean glucose, TIR and CV

Mean difference (mean glucose)

−11.1 mg dl-1

P < 0.001

DASH4D

Mean difference (time in range)

+5.2 percentage points

P < 0.001

DASH4D

Secondary outcomes

Glucose SD and time with hyperglycemia (>180 and >250 mg dl-1)

Lower with DASH4D diet

Time with hypoglycemia (<70 and <54 mg dl-1)

Similar across diets

Safety

Serious adverse events related to CGM or study diets
0

Original publication

DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial. Nat Med. Published 5 August 2025. doi:10.1038/s41591-025-03823-3

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