Association of Glucose Response Shape in Oral Glucose Tolerance Test (OGTT) With Markers of Pancreatic Health and Inflammation Across Diverse Ages
Authors' conclusion
Shape of glucose response curve is a biomarker for glycemia measures and obesity-related inflammation across ages.
Study context
- Population
- Individuals of self-reported Black ancestry (adolescents, n = 276, age 16.3 ± 1.7 years; young adults, n = 486, age 37.7 ± 7.5 years), Thomas Jefferson University 2006–2011, and healthy individuals from Pennington Biomedical Research Center (n = 95, age 55.2 ± 9.9 years, 27.3% Black)
- Exposure
- OGTT glucose response shape: persistent increase vs monophasic vs biphasic
- Outcome
- Glycemic indices and inflammatory markers by OGTT glucose curve shape
Methodological detailsreanalysis of data from cross-sectional prospective clinical studies
- Reanalysis of data from cross-sectional prospective clinical studies
Main finding
As reported in the abstract
- Persistent increase curve associated with lower insulinogenic and Matsuda index, and phase 1 and phase 2 insulin secretion, but higher homeostatic model assessment for insulin resistance (HOMA-IR) and glucose AUC vs monophasic or biphasic
- Circulating inflammatory markers (C-reactive protein, plasminogen activator inhibitor-1, tumor necrosis factor α) higher and adiponectin lower in persistent increase
- Findings more prominent in adults vs adolescents
Observational data: associations, not effects.
Original publication
Association of Glucose Response Shape in OGTT With Markers of Pancreatic Health and Inflammation Across Diverse Ages. J Clin Endocrinol Metab. Published 5 August 2025. doi:10.
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