Advanced radiation-crosslinked CM-chitosan/gelatin hydrogel for diabetic ulcer treatment with reducing application frequency
Authors' conclusion
The radiation-crosslinked carboxymethyl-chitosan/gelatin hydrogel shows great potential as a promising modality for diabetic wound management, with both daily and alternate-day applications having immunomodulatory and pro-angiogenic functions.
Study context
- Population
- Full-thickness diabetic wound rat model; 2 patients with diabetes (case studies)
- Comparison
- Radiation-crosslinked CM-chitosan/gelatin hydrogel applied daily or on alternate days vs control
- Outcome
- Diabetic wound healing
Methodological detailsfull-thickness diabetic wound rat model, daily vs alternate-day application, 2 patient case studies
- Full-thickness diabetic wound rat model
- Daily vs alternate-day application
- 2 patient case studies
Main finding
As reported in the abstract
- Accelerated healing with enhanced re-epithelialization and dermal differentiation under the hydrogel
- Treated groups developed mature skin characteristics absent in control; well-organized collagen network
- Accelerated macrophage infiltration, phenotype shift and enhanced angiogenesis at different healing stages
Further findings
Case studies: alternate-day application in patients with diabetes
- Patients positive with alternate-day application
- 2
Original publication
Advanced radiation-crosslinked CM-chitosan/gelatin hydrogel for diabetic ulcer treatment with reducing application frequency. Diabetes Res Clin Pract. Published 2 April 2025. doi:10.
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