Adolescent BMI trajectory and associations with adult metabolic syndrome and offspring obesity
Main finding · Offspring obesityResult — go to the resultOdds ratio 2.76 95% CI 1.39–5.46Authors' conclusion
Intermittent adolescent obesity may not confer MetSyn risk during adulthood. However, maternal adolescent BMI trajectories that are persistently high may increase the odds of intergenerational obesity among offspring.
Study context
- Population
- Original participants of the National Heart, Lung, and Blood Institute (NHLBI) Growth and Health Study (1987–1997) and their children, 20-year follow-up (2016–2019)645 children
- Participants
- 624 participants
- Exposure
- Adolescent BMI trajectories vs persistently normal BMI trajectory
- Weight loss then gainn = 62
- Persistently normaln = 374reference
- Persistently high BMIn = 127
- Weight gain then lossn = 61
- Outcome
- Adult metabolic syndrome (MetSyn) and offspring obesity
- Follow-up
- 20-year follow-up
Methodological detailslatent trajectory modeling, mediation analysis, confounder-adjusted
- Latent trajectory modeling
- Mediation analysis
- Confounder-adjusted
Main finding
Offspring obesity
Odds ratio
2.76
95% CI 1.39–5.46
Persistently high BMIvs Persistently normal
OR 2.76 (95% CI 1.39–5.46)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Adolescent BMI trajectory and associations with adult metabolic syndrome and offspring obesity. Obesity (Silver Spring). Published 25 May 2023. doi:10.
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