Positive effect of leptin substitution on mood and behaviour in patients with congenital leptin deficiency
Authors' conclusion
Metreleptin substitution improved indices of physical activity and psychological wellbeing in patients with CLD. This suggests that reduced leptin concentrations might be in part responsible for emotional and behavioural changes seen during starvation.
Study context
- Population
- Patients with congenital leptin deficiency (CLD), filmed in a play situation
- Participants
- 7 patients
- Comparison
- Before vs after short- and long-term metreleptin substitution
- Outcome
- Video ratings by six independent, blinded investigators of motor activity, social interaction, emotionality and mood (higher scores = improvements)
Methodological detailsblinded raters, specifically developed scales
- Blinded raters
- Specifically developed scales
Main finding
As reported in the abstract
Mean total score · short term
Before substitution
17.7
mean · ± 4.1
Short-term
22.6
mean · ± 6.6
P = 0.039
Further findings
| Outcome | Short-term substitution | P value |
|---|---|---|
| Mean motor activity score · short termShort-term vs Before substitution · significantly increased | mean 5.1 ± 1.5 | P = 0.023 |
| Mean social interaction score · short termShort-term vs Before substitution · significantly increased | mean 6.2 ± 1.7 | P = 0.016 |
- Mean motor activity score: Before substitution mean 4.1 ± 1.1
- Mean social interaction score: Before substitution mean 4.6 ± 1.1
All four scales and total score · long term
- After long-term substitution, means of all four single scales and of total score were even higher than at short-term follow-up
Treatment pause of 3 months
- In 2 children, all four scale scores fell below substitution levels during the pause and rose again after restart
Original publication
Positive effect of leptin substitution on mood and behaviour in patients with congenital leptin deficiency. Pediatr Obes. Published 24 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →