Efficacy and safety of modified fasting therapy for weight loss in 2054 hospitalized patients
Authors' conclusion
At present this study is the largest retrospective population-based study about modified fasting therapy. The results from 2054 patients showed that the modified fasting therapy lasting 7 days was efficient and safe. It led to improvements in physical health and body weight-associated indicators, as well as body composition and relevant cardiovascular risk factors.
Study context
- Population
- Hospitalized fasting patients
- Participants
- 2,054 participants
- Exposure
- Before vs after 7 days of modified fasting therapy
- Modified fasting therapyn = 2,054
- Outcome
- Changes in clinical efficacy biomarkers, safety indicators and body composition
- Follow-up
- Before and after 7 days of fasting
Methodological detailsobservational, single-group before–after
- Observational
- Single-group before–after
Main finding
As reported in the abstract
Efficacy · after 7 days
- Significant reductions in body weight, BMI, abdominal circumference, systolic and diastolic blood pressure
- Blood glucose and body composition indicators improved to various extents (all p < 0.05)
Observational data: associations, not effects.
Further findings
Subgroup analysis
- Patients with CVD benefited from modified fasting therapy
Safety
Safety indicators
- Small increase in liver function, kidney function, uric acid, electrolytes, blood count, coagulation and uric biomarkers
Original publication
Efficacy and safety of modified fasting therapy for weight loss in 2054 hospitalized patients. Obesity (Silver Spring). Published 19 May 2023. doi:10.
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