Liraglutide versus semaglutide for weight reduction—a cost needed to treat analysis
Authors' conclusion
Semaglutide provides significantly better value for money than liraglutide for weight reduction.
Study context
- Population
- Weight reduction with higher-dose GLP-1 agonists; data from the STEP 1 and SCALE trials
- Comparison
- Semaglutide vs liraglutide for weight reduction
- Outcome
- Cost needed to treat to achieve a 1% reduction in body weight
Methodological detailsscenario analysis, drug costs based on US GoodRx prices as of October 2022
- Scenario analysis
- Drug costs based on US GoodRx prices as of October 2022
Main finding
As reported in the abstract
Cost needed to treat per 1% of body weight reduction
Liraglutide
$3256
95% CI $3032-$3517
Semaglutide
$1845
95% CI $1707-$1989
Further findings
| Outcome | Semaglutide | Liraglutide |
|---|---|---|
| Weight loss | 12.4% (95% CI 11.5%–13.4%) | 5.4% (95% CI 5%–5.8%) |
| Total cost of therapy during the trial | $22,878 | $17,585 |
- Weight loss: abstract attributes liraglutide to STEP 1 and semaglutide to SCALE in results, but to SCALE and STEP 1 respectively in methods
Original publication
Liraglutide versus semaglutide for weight reduction—a cost needed to treat analysis. Obesity (Silver Spring). Published 19 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →