Neural correlates of decreased impulsivity during delay discounting task after laparoscopic sleeve gastrectomy
Authors' conclusion
These findings indicate that decreased choice impulsivity following LSG was associated with the changes in regions involved in executive control, reward evaluation, interoception, and prospection. This study may provide neurophysiological support for the development of nonoperative treatments such as brain stimulation for individuals with obesity and overweight.
Study context
- Population
- Individuals with obesity undergoing laparoscopic sleeve gastrectomy, and normal-weight controls
- Participants
- 29 vs 30
- Comparison
- Obesity (OB) before vs 1 month after laparoscopic sleeve gastrectomy (LSG), compared with normal-weight controls
- OBn = 29
- Normal weightn = 30reference
- Outcome
- LSG-induced changes in choice impulsivity (delay discounting) and neural correlates
- Follow-up
- 1 month after LSG
Methodological detailsfunctional MRI, delay discounting task, pre–post comparison, normal-weight controls matched for gender and age
- Functional MRI
- Delay discounting task
- Pre–post comparison
- Normal-weight controls matched for gender and age
Main finding
As reported in the abstract
Choice impulsivity and neural correlates
- OB exhibited significantly reduced discounting rate after LSG
- Hyperactivation in dorsolateral prefrontal cortex, right caudate and dorsomedial prefrontal cortex decreased in OB after LSG
- Increased activation in bilateral posterior insula and caudate–dorsomedial prefrontal cortex functional connectivity after LSG (compensatory effects)
- Changes associated with decreased discounting rate and BMI and improved eating behaviors
Original publication
Neural correlates of decreased impulsivity during delay discounting task after laparoscopic sleeve gastrectomy. Obesity (Silver Spring). Published 19 May 2023. doi:10.
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