Adiposity associates with lower plasma resolvin E1 (Rve1): a population study
Authors' conclusion
This population study suggests that a deficiency in plasma RvE1 may occur in response to increasing adiposity. This observation could be relevant to ongoing inflammation that associates with CVD and other chronic diseases.
Study context
- Population
- 27-year-olds from the Australian Raine Study
- Participants
- 978 participants
- Outcome
- Plasma SPM in relation to sex, lifestyle and cardiovascular disease (CVD) risk factors
Methodological detailspopulation-based, Plasma SPM pathway intermediates, SPM and LTB4 measured by LCMSMS; Pearson correlations, multiple regression, unpaired t-tests or ANOVA
- Population-based
- Plasma SPM pathway intermediates, SPM and LTB4 measured by LCMSMS; Pearson correlations, multiple regression, unpaired t-tests or ANOVA
Main finding
As reported in the abstract
- Women vs men: higher 17-HDHA
- p = 0.01
- Women vs men: lower RvE1
- p < 0.0001
- Women vs men: lower RvD1
- p = 0.05
- Univariate: obesity associated with lower RvE1
- p = 0.002
- Univariate: smoking associated with increased RvE1
- p < 0.001
- Univariate: higher alcohol consumption associated with increased RvE1
- p < 0.001
Observational data: associations, not effects.
Original publication
Adiposity associates with lower plasma resolvin E1 (Rve1): a population study. Int J Obes (Lond). Published 12 February 2024. doi:10.
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