Adipokines and Transitions in Metabolic Health Over Time: The Atherosclerosis Risk In Communities (ARIC) Study
Authors' conclusion
Leptin and adiponectin are differentially linked to the likelihood of worsening and improving metabolic health over time. Adipokines should be explored as targets to improve metabolic health and decrease the risk of future cardiovascular events.
Study context
- Population
- Adults attending ARIC Visits 2 (1990–1992) and 4 (1996–1998); mean age 58, 56% female, 21% Black; metabolic health: healthy (no metabolic syndrome (MetS) or DM), unhealthy without DM, unhealthy with DM
- Participants
- 8,423 adults
- Exposure
- Visit 2 adiponectin and leptin and 6-year metabolic health transitions
- Outcome
- Transitions in metabolic health (progression healthy to unhealthy; regression unhealthy to healthy)
- Follow-up
- 6 years
Methodological detailscommunity-based (ARIC), stratified by obesity
- Community-based (ARIC)
- Stratified by obesity
Main finding
As reported in the abstract
Adiponectin: progression healthy to unhealthy, OR
0.53 (0.48-0.57) (95% CI)
Leptin: progression healthy to unhealthy, OR
2.22 (2.01-2.47) (95% CI)
Adiponectin: regression unhealthy to healthy, OR
1.58 (1.42-1.76) (95% CI)
Leptin: regression unhealthy to healthy, OR
0.68 (0.60-0.78) (95% CI)
Observational data: associations, not effects.
Further findings
Obesity strata (body mass index (BMI) ≥30 kg/m²)
- Similar patterns across obesity strata
Adjustment for BMI
- Adiponectin associations similar; leptin associations significantly attenuated
Original publication
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