Additive effect of admission hyperglycemia on left ventricular stiffness in patients following acute myocardial infarction verified by cardiac magnetic resonance (CMR) tissue tracking
Authors' conclusion
Hyperglycemia may exacerbate LV myocardial stiffness in patients experienced first AMI, leading to reduction in LV strains. aBGL was an independent indicator of impaired LV global PS in AMI patients. Blood glucose monitoring is more valuable for AMI patients with diabetes.
Study context
- Population
- Patients with first acute myocardial infarction (AMI) who underwent CMR examination75 hyperglycemic
- Participants
- 171 patients
- Exposure
- Admission hyperglycemia vs normoglycemia in AMI
- Admission blood glucose level (aBGL) < 7.8 mmol/Ln = 96reference
- aBGL 7.8-11.1 mmol/Ln = 41
- aBGL ≥ 11.1 mmol/Ln = 34
- Outcome
- LV global radial/circumferential/longitudinal peak strain (PS), peak systolic strain rate (PSSR) and peak diastolic strain rate (PDSR) by CMR tissue tracking
Main finding
As reported in the abstract
LV global PS, PSSR and PDSR
- Hyperglycemia vs normoglycemia: Left ventricular (LV) global peak strain (PS), peak systolic strain rate (PSSR) and peak diastolic strain rate (PDSR) decreased in radial, circumferential and longitudinal directions (all P < 0.05)
- aBGL 7.8-11.1 vs < 7.8 mmol/L: decreased radial and longitudinal PS, radial PSSR, and radial and longitudinal PDSR (all P < 0.05)
- aBGL ≥ 11.1 vs < 7.8 mmol/L: decreased PS, PSSR and PDSR in all three directions (all P < 0.05)
- aBGL ≥ 11.1 vs 7.8-11.1 mmol/L: decreased longitudinal PSSR (P < 0.05)
Observational data: associations, not effects.
Further findings
Diabetes subgroups
- Differences more obvious in patients with diabetes than without
Independent association of aBGL with LV global PS (multivariate analysis)
- Radial PS β
- - 0.166, P = 0.003
- Longitudinal PS β
- 0.143, P = 0.008
Original publication
Additive effect of admission hyperglycemia on left ventricular stiffness in patients following acute myocardial infarction verified by CMR tissue tracking. Cardiovasc Diabetol. Published 20 June 2024. doi:10.
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