Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes
Authors' conclusion
GPR146 expression is associated with serum lipids and metabolically-relevant transcriptomic changes in EAT similar to SGLT2i-associated ones.
Study context
- Population
- Patients undergoing coronary artery bypass grafting; 37 male, 23 with T2D, median age 68.50 (Q1-Q3: 63.00–72.00) years, BMI 28.39 (26.06–31.49) kg/m²RNA-seq in 20
- Participants
- 46 patients
- Outcome
- GPR146 (cholesin receptor) mRNA expression and associated genes and clinical factors in cardiovascular and associated adipose tissues
Main finding
As reported in the abstract
- GPR146 expression in adipose tissues significantly correlated with BMI, C-peptide, total cholesterol and LDL concentrations
- Selected metabolic pathways significantly and positively enriched in GPR146-dependent manner
- GPR146-coexpressed genes included key lipid metabolism regulators (fatty acid metabolism, tricarboxylic acid cycle, peroxisomal metabolism); these correlated positively with serum LDL, HDL and total cholesterol
- SGLT2i treatment associated with inversion of GPR146-related signature in EAT
Original publication
Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes. Cardiovasc Diabetol. Published 20 June 2024. doi:10.
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