Adaptive Thermogenesis After Hypocaloric Low‐Carbohydrate Versus Low‐Fat Diets in African American Women: A Secondary Analysis
Authors' conclusion
AA women with low S I on low-CHO diets do not experience AT, which can contribute to the superiority of this dietary approach in inducing weight and fat mass loss.
Study context
- Population
- African American women with obesity40 finished
- Participants
- 69 women
- Comparison
- Hypocaloric low-CHO vs low-fat diet
- Primary endpoint
- Magnitude of adaptive thermogenesis (AT)
- Follow-up
- Week 13
Methodological detailshypocaloric diets, all food provided, 10-week intervention + 4-week weight stabilization
- Hypocaloric diets
- All food provided
- 10-week intervention + 4-week weight stabilization
Primary result
As reported in the abstract
AT (overall cohort)
Adaptive thermogenesis (AT) at level of resting EE (REE)
−75 ± 136 kcal/day, p < 0.003, n = 38
No significant AT at level of TEE
−80 ± 288 kcal/day, p = 0.086, n = 40
Further findings
| Outcome | Low-CHO | Low-fat | P value |
|---|---|---|---|
| AT at level of TEE in women with low insulin sensitivity (S I) · Week 13Greater AT with low-fat | 127 ± 239 kcal/day | −202 ± 213 kcal/day | P < 0.006 |
Weight loss
- Average weight loss, no differences between groups
- 6.3 ± 3.9 kg
Original publication
Adaptive Thermogenesis After Hypocaloric Low‐Carbohydrate Versus Low‐Fat Diets in African American Women: A Secondary Analysis. Obesity (Silver Spring). Published 10 September 2025. doi:10.
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