Acute kidney injury in hospitalised patients with type 2 diabetes: Associations with continuous glucose monitoring‐based glucose levels, mortality, and intensive care unit (ICU) admission
Main finding · TIR (3.9-10.0 mmol/L)Result — go to the resultReduction in TIR 7.3 %-point 95% CI 0.3–14.2Authors' conclusion
AKI and high plasma creatinine are associated with hyperglycemia, in-hospital mortality, referral to ICU, and 30-day unscheduled readmissions in hospitalised patients with type 2 diabetes. These findings challenge the prevailing focus on hypoglycemia prevention during AKI, emphasising the importance of addressing hyperglycemia as well.
Study context
- Population
- Non-critically ill hospitalised patients with T2D on basal-bolus insulin monitored by continuous glucose monitoring (CGM)
- Participants
- 166 participants
- Exposure
- Acute kidney injury (AKI) vs no AKI
- Outcome
- CGM-based glycaemic outcomes:
- TIR
- TAR
- TBR
Methodological detailsKidney function measured daily via plasma creatinine
- Kidney function measured daily via plasma creatinine
Main finding
TIR (3.9-10.0 mmol/L)
Reduction in time in range (TIR)
7.3 %-point
95% CI 0.3–14.2
As reported in the abstract
Observational data: associations, not effects.
Further findings
In-hospital mortality and ICU admission
- Risk with AKI approximately tenfold increased
Readmission within 30 days
- Risk with AKI twice as high
TIR per 100 μmol/L increase in plasma creatinine
- TIR decrease
- 7.6%-point (95% CI 2.6-12.5)
Original publication
Acute kidney injury in hospitalised patients with type 2 diabetes: Associations with continuous glucose monitoring‐based glucose levels, mortality, and ICU admission. Diabet Med. Published 10 April 2026. doi:10.
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