Pathway‐Specific Polygenic Risk Scores and Cardiorenal Complications in Asians With Type 2 Diabetes
Authors' conclusion
In a multi-ethnic Asian population, pathway-specific genetic susceptibility was differentially associated with cardiorenal outcomes and related circulating proteins. These findings suggest the potential relevance of biologically informed genetic pathways in diverse populations and warrant validation in independent cohorts.
Study context
- Population
- Multi-ethnic Asian individuals with T2D, prospective SMART2D cohort
- Participants
- 2,057 individuals
- Exposure
- T2D pathway-specific polygenic risk scores and cardiorenal outcomes
- Outcome
- Incident end-stage kidney disease (ESKD), heart failure (HF), rapid decline in kidney function (RDKF) and circulating proteins linked to cardiorenal complications
Methodological detailsmulti-ethnic, genetic association study
- Multi-ethnic
- Genetic association study
Main finding
As reported in the abstract
Beta-cell -PI pathway-specific polygenic risk scores (psPRS) and end-stage kidney disease (ESKD): HR
0.81
95% CI 0.69–0.95
Beta-cell -PI psPRS and rapid decline in kidney function (RDKF): OR
0.81
95% CI 0.69–0.94
Beta-cell -PI psPRS and heart failure (HF): HR
0.86
95% CI 0.74–1.00
Lipodystrophy psPRS and higher odds of RDKF: OR
1.21
95% CI 1.04–1.41
Observational data: associations, not effects.
Original publication
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