Acute effect of impact and resistance exercise on Wnt signaling modulators, bone and cartilage metabolism
Authors' conclusion
Impact and resistance exercise transiently increased Wnt signaling inhibitors. Resistance exercise increased a marker of cartilage turnover but did not affect markers of bone turnover. Impact exercise did not affect cartilage turnover markers.
Study context
- Population
- Healthy young men, mean (SD) age 23.4 (2.9) yr
- Participants
- 26 men
- Comparison
- Impact or resistance exercise vs supine rest control
Methodological detailsrandom order, control trial
- Random order
- Control trial
Primary result
As reported in the abstract
Biomarkers of bone turnover, Wnt signaling and cartilage metabolism (% change) · immediately and 24 h post-exercise
- PINP immediately post-exercise, Impact: mean [95% CI] % change
- + 10.8[4.8, 17.2]%, p = .002
- PINP 24 h post-exercise, Impact: mean [95% CI] % change
- +7.4 [0.0, 15.3]%, p = .05
- PINP, Resistance
- no effect
- Sclerostin immediately post-exercise, Impact only: transient increase
- +36.3 [24.6, 49.3]%, p < .001
- DKK1 immediately post-exercise, Impact: transient increase
- +32.4 [23.1, 42.4]%, p < .001
- DKK1 immediately post-exercise, Resistance: transient increase
- +30.3 [22.8, 38.4]%, p < .001
- Cartilage oligomeric matrix protein immediately post-exercise, Resistance only: increase
- +36.2 [16.0, 59.8]%, p < .001
Original publication
Acute effect of impact and resistance exercise on Wnt signaling modulators, bone and cartilage metabolism. J Bone Miner Res. Published 19 September 2025. doi:10.
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