Osteoporosis, bone & mineral

A nomogram for predicting surgery outcome of tumor-induced osteomalacia: a case-control study

Osteoporos IntPublished Retrospective case-control study

Authors' conclusion

This study established a prognostic model for the preoperative prediction of surgical outcomes for TIO. This model can be used as a reference in clinical practice for the development of individualized treatment strategies.

Study context

Population
Patients with tumor-induced osteomalacia (TIO) who underwent surgical treatment
Participants
309 patients
Comparison
Nomogram derived in training set vs validation set
  • Training setn = 222
  • Validation setn = 87
Outcome
Surgical outcomes of patients with TIO
Methodological detailssingle-center
  • Single-center

Main finding

As reported in the abstract

Nomogram discrimination for surgical outcome
GroupValuep
Training setC-index 0.864p < 0.001
Validation setAUC 0.782p < 0.001

Value

Training setC-index 0.864
Validation setAUC 0.782

p

Training setp < 0.001
Validation setp < 0.001

Observational data: associations, not effects.

Original publication

A nomogram for predicting surgery outcome of tumor-induced osteomalacia: a case-control study. Osteoporos Int. Published 18 September 2025. doi:10.1007/s00198-025-07686-9

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