A systematic review and meta-analysis of the effects of probiotics on bone outcomes in rodent models
Authors' conclusion
The syntheses support probiotics as a strategy to improve bone outcomes in rodent models.
Study context
- Population
- Rodent models (intact and ovariectomized)
- Participants
- 71 studies
- Comparison
- Oral probiotic supplementation vs no supplementation
- Outcome
- Volumetric bone mineral density (BMD) (volumetric BMD (vBMD)), bone volume fraction (BV/TV) and cortical thickness (Ct.Th) at femur, tibia, spine
Methodological detailsanalyses by study model (intact, ovariectomized) and bone site (femur, tibia, spine), heterogeneity explored by probiotic genus, sex, type of rodent
- Analyses by study model (intact, ovariectomized) and bone site (femur, tibia, spine)
- Heterogeneity explored by probiotic genus, sex, type of rodent
Pooled result
As reported in the abstract
vBMD, BV/TV and Ct.Th (SMD)
Probiotics vs ControlSMD (95% CI)P value
Intact rodents, femur vBMD; I2 = 3%
0.43(0.13–0.74)
P < 0.05Intact rodents, femur BV/TV; I2 = 57%
0.63(0.25–1.02)
P < 0.05Ovariectomized, femur vBMD; I2 = 3%
1.28(1.01–1.55)
P < 0.05Ovariectomized, tibia vBMD; I2 = 67%
1.29(0.52–2.05)
P < 0.05Ovariectomized, spine vBMD; I2 = 26%
1.47(0.97–1.97)
P < 0.05Ovariectomized, femur BV/TV; I2 = 56%
1.16(0.80–1.52)
P < 0.05Ovariectomized, tibia BV/TV; I2 = 79%
2.13(1.09–3.17)
P < 0.05Ovariectomized, spine BV/TV; I2 = 76%
2.04(1.17–2.90)
P < 0.05Ovariectomized, tibia Ct.Th; I2 = 82%
2.35(0.72–3.97)
Original publication
A systematic review and meta-analysis of the effects of probiotics on bone outcomes in rodent models. J Bone Miner Res. Published 15 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →