A Prospective Multicenter Study Examining the Relationship Between Thyroid Cancer Treatment Outcomes and the Presence of Autoimmune Thyroiditis
Main finding · Evidence of disease (structural/biochemical incomplete response) vs excellent/indeterminate responseResult — go to the resultOdds ratio 1.86 CI 1.3–2.6Authors' conclusion
In this large prospective series, biochemical persistence was more frequent, at 1-year follow-up, in AT patients. However, there was no significant association between the presence of AT and structural persistence of disease.
Study context
- Population
- Consecutive differentiated thyroid cancer (DTC) patients in the Italian Thyroid Cancer Observatory (ITCO) database; 75% female; American Thyroid Association (ATA) risk 51% low, 41.3% intermediate, 7.6% high
- Participants
- 4,233 patients
- Exposure
- Autoimmune thyroiditis vs no autoimmune thyroiditis (AT)
- ATn = 1,552
- Outcome
- Thyroid cancer treatment outcomes: evidence of disease (structural/biochemical incomplete response) vs excellent/indeterminate response
- Follow-up
- 1-year follow-up
Methodological detailsprospectively collected data, propensity score matching, consecutive patients
- Prospectively collected data
- Propensity score matching
- Consecutive patients
Main finding
As reported in the abstract
Evidence of disease (structural/biochemical incomplete response) vs excellent/indeterminate response
Odds ratio
1.86
CI 1.3–2.6
P = 0.0001
By group
ATvs noAT
OR 1.86 (CI 1.3–2.6); P = 0.0001
Observational data: associations, not effects.
Further findings
Structural persistence · 1-year follow-up · no statistically significant difference · after propensity score matching
P = 0.35
Baseline features before matching
- AT patients younger, with smaller and bilateral tumours
- P < 0.0001
- AT more often ATA low/intermediate risk; ATA high risk more frequent in noAT
- P = 0.004
ATA risk at diagnosis
- Elevated risk associated with ATA intermediate and high risk at diagnosis remained consistently statistically significant
Original publication
A Prospective Multicenter Study Examining the Relationship Between Thyroid Cancer Treatment Outcomes and the Presence of Autoimmune Thyroiditis. Thyroid. Published 19 October 2023. doi:10.
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