Data-driven Thyroglobulin Cutoffs for Low- and Intermediate-risk Thyroid Cancer Follow-up: ITCO Real-world Analysis
Authors' conclusion
This real-world study provides evidence for the continued reliability of 1-year serum Tg levels. The data-driven Tg thresholds proposed offer valuable insights for clinical decision-making in patients undergoing total thyroidectomy with or without RRA.
Study context
- Population
- Patients with DTC with 5 years of follow-up and negative anti-Tg antibodies, centres of the Italian Thyroid Cancer Observatory database
- Participants
- 540 patients
- Exposure
- Total thyroidectomy with radioiodine remnant ablation (RRA) vs thyroidectomy alone
- Outcome
- Detection of structural disease
- Follow-up
- Within 5 years
Methodological detailsmulticentre, real-world
- Multicentre
- Real-world
Main finding
As reported in the abstract
Performance of 1-year serum Tg: data-driven thresholds (97th percentile of Tg in disease-free individuals) · 1-year follow-up visit
| Group | Value | NPV |
|---|---|---|
| Thyroidectomy alone | Thyroglobulin (Tg) threshold 1.97 ng/mL | 98% |
| RRA | Tg threshold 0.84 ng/mL |
Value
Thyroidectomy aloneTg threshold 1.97 ng/mL
RRATg threshold 0.84 ng/mL
NPV
Thyroidectomy alone98%
RRA— not stated in the abstract
Observational data: associations, not effects.
Further findings
Median Tg in disease-free patients, with vs without radioiodine
- Median Tg did not differ between patients treated with or without radioiodine (26 patients with structural disease excluded)
Original publication
Data-driven Thyroglobulin Cutoffs for Low- and Intermediate-risk Thyroid Cancer Follow-up: ITCO Real-world Analysis. J Clin Endocrinol Metab. Published 16 August 2024. doi:10.
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