A predictive model for medium‐term weight loss response in people with type 2 diabetes engaging in behavioural weight management interventions
Authors' conclusion
Not attaining a weight loss threshold of 0.5% early in weight management programmes may identify participants who would benefit from alternative interventions.
Study context
- Population
- People with T2D in behavioural weight management programmes (LookAHEAD, WRAP, NHS Greater Glasgow and Clyde Weight Management Service)
- Outcome
- Medium-term weight loss response (>5% body weight)
- Follow-up
- 3 years (NHS-GGCWMS); 4 years (LookAHEAD); 5 years (WRAP)
Methodological detailslongitudinal analyses, secondary analysis of LookAHEAD and WRAP trials and NHS routine data, external validation in WRAP
- Longitudinal analyses
- Secondary analysis of LookAHEAD and WRAP trials and NHS routine data
- External validation in WRAP
Performance
As reported in the abstract
Predictors of medium-term weight loss (>5%) in NHS-GGCWMS · 3 years
- Lost weight over 3 years in National Health Service Greater Glasgow and Clyde Weight Management Service (NHS-GGCWMS) (n=1152)
- 139 (12%)
- Early weight change per 1% weight loss (strongest predictor), OR
- 2.22 (1.92-2.56) (95% CI)
- Losing 0.5% weight in first 4 weeks: sensitivity
- 89.9%
- Losing 0.5% weight in first 4 weeks: specificity
- 49.5%
- Losing 0.5% weight in first 4 weeks: NPV
- 97.3%
Further findings
Baseline predictors in LookAHEAD and WRAP
- Only baseline variables consistently associated with weight loss response were female sex and older age
Overall in-programme weight change · 3 years (NHS-GGCWMS); 5 years (WRAP)
- Overall in-programme weight change also associated with weight loss response
Original publication
A predictive model for medium‐term weight loss response in people with type 2 diabetes engaging in behavioural weight management interventions. Diabetes Obes Metab. Published 14 June 2024. doi:10.
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